inflammation of the linings of the brain (aseptic meningitis with fever).inflammation of the digestive tract (Crohn's disease).inflammation of the connective tissues ( lupus erythematosus syndrome).inflammation and bleeding in the small blood vessels (Henoch-Schönlein vasculitis).bleeding from the nasal cavity ( epistaxis).allergic reaction to an injection of foreign protein.abnormally heavy bleeding at menstruation.Rarely, the use of Brustan Tablet may cause the following side-effects: Before having surgery during the use of Brustan, discuss with your doctor and dentist about the medicinal products you use including prescription/non-prescription/herbal medicines. Using Brustan in patients with a history of seizure may cause an excess level of acids in the body (metabolic acidosis). Patients with a history of abnormal kidney, liver and heart functioning, elderly patients, patients taking diuretics and ACE inhibitors may develop the reduced functioning of the kidney. Use of ibuprofen in patients with a history of liver failure or abnormal liver functioning may cause severe reactions such as jaundice, fatal liver inflammation (fatal hepatitis) and allergic rashes ( eosinophilia).
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Ibuprofen is acidic in nature and excreted in urine so the excess amount of ibuprofen may be removed by using basic (alkali) drugs and inducing urine excretion (diuresis).īefore you use Brustan, tell your doctor of your medical and health history including the following: taking pain-killer (anti-inflammatory), warfarin, ticlopidine, phenytoin, chloramphenicol, probenecid, zidovudine, isoniazid, captopril, atenolol, losartan, digoxin, diuretics, lithium compounds, methotrexate, prednisolone, cortisone, metoclopramide, propantheline, tacrolimus, ciclosporin, sulphonyleureas, quinolone antibiotics, heart failure, chest pain ( angina), heart attack, bypass surgery, poor circulation of blood in the legs or feet due to blockage of blood arteries (peripheral artery disease), stroke, mini-stroke, high blood pressure, diabetes, high cholesterol, family history of heart disease or stroke, smoking, liver disease, liver failure, liver swelling ( hepatitis), kidney disease, kidney failure, difficulty in urination, heavy drinker, heartburn, indigestion, stomach ulcer, stomach problems, blood in vomiting, bleeding in stools, allergic skin reactions (Stevens-Johnson syndrome), asthma, vision problems, inflammation in bowel (ulcerative colitis or Crohn's disease), stomach and intestinal bleeding, swelling of feet or ankles, diarrhea, smallpox, heriditical genetic skin or neurological disorders ( porphyria), inflammation in connective tissues ( lupus erythematosus), or seizures. Activated charcoal should be used to absorb the excess amount of ibuprofen into the body. In the case of ibuprofen poisoning, the stomach should be emptied by lavage or vomiting.
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Methionine should only be used within 10 hours after taking paracetamol overdose. Methionine is given orally as 2.5 g in every 4 hours interval up to 10 g.
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route) for 15 minutes, which is followed by intravenous infusion of 50 mg/kg or 22.7 mg/lb of acetylcysteine in 500 ml 5% glucose for 4 hours and 100 mg/kg or 45.45 mg/lb of acetylcysteine in 1 litre 5% glucose for 16 hours. Initially 150 mg/kg or 68.18 mg/lb of acetylcysteine in 200 ml 5% glucose is given through blood veins (intravenous or I. Acetylcysteine should be used within 8 hours of taking paracetamol overdose. For reversing the liver injury antidote therapy of acetylcysteine and methionine should be used as soon as possible. In the case of paracetamol poisoning, immediate medical treatment is given to overcome the risk of liver injury and emptying of the stomach (gastric lavage) should also be considered.